Helen S. Mayberg
Abstract
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D
uring the last 20 years of neuroscience research, we have witnessed a fundamental
shift in the conceptualization of psychiatric disorders, with the dominant
psychological and neurochemical theories of the past now complemented by a growing
emphasis on developmental, genetic, molecular, and brain circuit models. Facilitating
this evolving paradigm shift has been the growing contribution of functional
neuroimaging, which provides a versatile platform to characterize brain circuit
dysfunction underlying specific syndromes as well as changes associated with their
successful treatment. Discussed here are converging imaging findings that established
a rationale for testing a targeted neuromodulation strategy, deep brain stimulation,
for treatment-resistant major depression.
