FGFR3 knockdown in RT112 bladder cancer cells inhibits proliferation and induces G1 cell-cycle arrest in vitro, and it suppresses tumor growth in vivo.
Three different FGFR3 shRNAs were cloned into a Tet-inducible expression vector. RT112 cells stably expressing FGFR3 shRNAs or a control shRNA were established with puromycin selection. (
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