Citations to this article


Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle–triglyceride and –cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.


Kimber L. Stanhope ... Lars Berglund, Peter J. Havel


Total citations by year

Year: 2014 2013 2012 2011 2010 2009 Total
Citations: 56 98 75 72 58 19 378
Citation information

Citations to this article in year 2011 (72)

Title and authors Publication Year
Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter
IJ Lodhi, X Wei, CF Semenkovich
Trends in Endocrinology & Metabolism 2011
The Metabolic Syndrome
S Devaraj, D Siegel, I Jialal
The Metabolic Syndrome 2011
Hepatic fatty acid partitioning
L Hodson, KN Frayn
Current Opinion in Lipidology 2011
Postprandial lipoprotein metabolism: VLDL vs chylomicrons
K Nakajima, T Nakano, Y Tokita, T Nagamine, A Inazu, J Kobayashi, H Mabuchi, KL Stanhope, PJ Havel, M Okazaki, M Ai, A Tanaka
Clinica Chimica Acta 2011
Dietary fructose and risk of metabolic syndrome in adults: Tehran Lipid and Glucose study
F Hosseini-Esfahani, Z Bahadoran, P Mirmiran, S Hosseinpour-Niazi, F Hosseinpanah, F Azizi
Nutrition & Metabolism 2011
Effects of Diet on High-Density Lipoprotein Cholesterol
PW Siri-Tarino
Current Atherosclerosis Reports 2011
Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function
PW Caton, J Kieswich, MM Yaqoob, MJ Holness, MC Sugden
Diabetologia 2011
Journal of Diabetes NEWS
BM Kozak, MY Tjota, KL Close
Journal of Diabetes 2011
Non-alcoholic fatty liver disease
BW Smith, LA Adams
Critical Reviews in Clinical Laboratory Sciences 2011
Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice
KM Mellor, JR Bell, MJ Young, RH Ritchie, LM Delbridge
Journal of Molecular and Cellular Cardiology 2011
Metabolic and behavioural effects of sucrose and fructose/glucose drinks in the rat
A Sheludiakova, K Rooney, RA Boakes
European Journal of Nutrition 2011
Redox homeostasis and posttranslational modifications/activity of phosphatase and tensin homolog in hepatocytes from rats with diet-induced hepatosteatosis
A Alisi, G Bruscalupi, A Pastore, S Petrini, N Panera, M Massimi, G Tozzi, S Leoni, F Piemonte, V Nobili
The Journal of Nutritional Biochemistry 2011
The Impact of Fructose on Renal Function and Blood Pressure
M Kretowicz, RJ Johnson, T Ishimoto, T Nakagawa, J Manitius
International Journal of Nephrology 2011
Neighborhood and Parental Supports for Physical Activity in Minority Adolescents
DK Wilson, HG Lawman, M Segal, S Chappell
American Journal of Preventive Medicine 2011
The search for compounds that stimulate thermogenesis in obesity management: from pharmaceuticals to functional food ingredients : Thermogenic bioactive food ingredients
AG Dulloo
Obesity Reviews 2011
Insulin resistance and bariatric surgery : Insulin resistance and bariatric surgery
RS Rao, R Yanagisawa, S Kini
Obesity Reviews 2011
Guía de la ESC/EAS sobre el manejo de las dislipemias
Ž Reiner, AL Catapano, GD Backer, I Graham, MR Taskinen, O Wiklund, S Agewall, E Alegría, MJ Chapman, P Durrington, S Erdine, J Halcox, R Hobbs, J Kjekshus, PP Filardi, G Riccardi, RF Storey, D Wood
Revista Española de Cardiología 2011
Sugar-Sweetened Beverage Taxes in Brazil
RM Claro, RB Levy, BM Popkin, CA Monteiro
American journal of public health 2011
Hepatic Oxidative Stress in Fructose-Induced Fatty Liver Is Not Caused by Sulfur Amino Acid Insufficiency
SS Kunde, JR Roede, MB Vos, ML Orr, YM Go, Y Park, TR Ziegler, DP Jones
Nutrients 2011
Comparative Effects of Fructose and Glucose on Lipogenic Gene Expression and Intermediary Metabolism in HepG2 Liver Cells
KM Hirahatake, JK Meissen, O Fiehn, SH Adams
PloS one 2011
Pediatric nonalcoholic fatty liver disease, metabolic syndrome and cardiovascular risk
L Pacifico, V Nobili, C Anania, P Verdecchia, C Chiesa
World journal of gastroenterology : WJG 2011
Postprandial lipoprotein metabolism; VLDL vs chylomicrons
K Nakajima, T Nakano, Y Tokita, T Nagamine, A Inazu, J Kobayashi, H Mabuchi, KL Stanhope, PJ Havel, M Okazaki, M Ai, A Tanaka
Clinica chimica acta; international journal of clinical chemistry 2011
Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice
J Shirakawa, H Fujii, K Ohnuma, K Sato, Y Ito, M Kaji, E Sakamoto, M Koganei, H Sasaki, Y Nagashima, K Amo, K Aoki, C Morimoto, E Takeda, Y Terauchi
Diabetes 2011
Global Perspectives on Childhood Obesity
S Yaturu, SK Jain
Global Perspectives on Childhood Obesity 2011
Dietary Sugars Predict Chronic Disease Risk Factors in College Students:
SE Hirshberg, J Fernandes, KJ Melanson, JL Dwiggins, ES Dimond, IE Lofgren
Topics in clinical nutrition 2011