Advertisement

Citations to this article

Abstract

Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle–triglyceride and –cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.

Authors

Kimber L. Stanhope ... Lars Berglund, Peter J. Havel

×

Total citations by year in Crossref

Year: 2014 2013 2012 2011 2010 2009 Total
Citations: 48 64 44 44 35 12 247
Citation information

Citations to this article in Crossref (247)

Title and authors Publication Year
La consommation de fructose est-elle associée au syndrome métabolique ?
L Tappy, L Egli, F Theytaz, V Campos, NL Akaffou, P Schneiter
Cahiers de Nutrition et de Diététique 2012
Retinoids ameliorate insulin resistance in a leptin-dependent manner in mice
H Tsuchiya, Y Ikeda, Y Ebata, C Kojima, R Katsuma, T Tsuruyama, T Sakabe, K Shomori, N Komeda, S Oshiro, H Okamoto, K Takubo, S Hama, K Shudo, K Kogure, G Shiota
Hepatology 2012
Fructose intake during pregnancy up-regulates the expression of maternal and fetal hepatic sterol regulatory element-binding protein-1c in rats
Y Mukai, M Kumazawa, S Sato
Endocrine 2012
Obesity: Epidemiology, Pathophysiology, and Prevention, Second Edition
S Prasad, S Patchva, B Aggarwal
Obesity: Epidemiology, Pathophysiology, and Prevention, Second Edition 2012
Does fructose consumption contribute to non-alcoholic fatty liver disease?
L Tappy, KA Lê
Clinics and Research in Hepatology and Gastroenterology 2012
Role of Fructose-Containing Sugars in the Epidemics of Obesity and Metabolic Syndrome
KL Stanhope
Annual Review of Medicine 2012
Candy consumption was not associated with body weight measures, risk factors for cardiovascular disease, or metabolic syndrome in US adults: NHANES 1999-2004
CE O'Neil, VL Fulgoni, TA Nicklas
Nutrition Research 2011
Mechanisms Linking Nonalcoholic Fatty Liver Disease with Coronary Artery Disease
W Nseir, A Shalata, A Marmor, N Assy
Digestive Diseases and Sciences 2011
Effects of 4-week very-high-fructose/glucose diets on insulin sensitivity, visceral fat and intrahepatic lipids: an exploratory trial
G Silbernagel, J Machann, S Unmuth, F Schick, N Stefan, HU Häring, A Fritsche
British Journal of Nutrition 2011
Non-alcoholic fatty liver disease
BW Smith, LA Adams
Critical Reviews in Clinical Laboratory Sciences 2011
Metabolic and behavioural effects of sucrose and fructose/glucose drinks in the rat
A Sheludiakova, K Rooney, RA Boakes
European Journal of Nutrition 2011
Cardiovascular risk and dietary sugar intake: is the link so sweet?
L Mucci, F Santilli, C Cuccurullo, G Davì
Internal and Emergency Medicine 2011
ESC/EAS Guidelines for the management of dyslipidaemias
AL Catapano, Ž Reiner, GD Backer, I Graham, MR Taskinen, O Wiklund, S Agewall, E Alegria, MJ Chapman, P Durrington, S Erdine, J Halcox, R Hobbs, J Kjekshus, PP Filardi, G Riccardi, RF Storey, D Wood
Atherosclerosis 2011
Advances in Pediatric Nonalcoholic Fatty Liver Disease
AA Mencin, JE Lavine
Pediatric Clinics of North America 2011
High disaccharide intake associates with atherogenic lipoprotein profile
E Sonestedt, E Wirfält, P Wallström, B Gullberg, I Drake, J Hlebowicz, GN Fredrikson, B Hedblad, J Nilsson, RM Krauss, M Orho-Melander
British Journal of Nutrition 2011
Effects of dietary protein on lipid metabolism in high fructose fed humans
M Bortolotti, J Dubuis, P Schneiter, L Tappy
Clinical Nutrition 2011
Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter
IJ Lodhi, X Wei, CF Semenkovich
Trends in Endocrinology & Metabolism 2011
Direct association between dietary cholesterol intake and blood pressure: too good to be ‘entirely’ true
M Siervo
Journal of Hypertension 2011
The metabolic effects of a high fructose versus a high glucose diet in healthy overweight men
RD Johnston, MC Stephenson, H Crossland, SM Cordon, MA Taylor, GP Aithal, IA Macdonald
Proceedings of the Nutrition Society 2011
Hepatic fatty acid partitioning:
L Hodson, KN Frayn
Current Opinion in Lipidology 2011
Obesity and energy balance: is the tail wagging the dog?
JC Wells, M Siervo
European Journal of Clinical Nutrition 2011
Postprandial lipoprotein metabolism: VLDL vs chylomicrons
K Nakajima, T Nakano, Y Tokita, T Nagamine, A Inazu, J Kobayashi, H Mabuchi, KL Stanhope, PJ Havel, M Okazaki, M Ai, A Tanaka
Clinica Chimica Acta 2011
Hepatic fatty acid partitioning
L Hodson, KN Frayn
Current Opinion in Lipidology 2011
The Metabolic Syndrome
S Devaraj, D Siegel, I Jialal
The Metabolic Syndrome 2011
Dietary Sugars Predict Chronic Disease Risk Factors in College Students:
SE Hirshberg, J Fernandes, KJ Melanson, JL Dwiggins, ES Dimond, IE Lofgren
Topics in clinical nutrition 2011

Advertisement
Advertisement