Advertisement

Citations to this article

Abstract

Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle–triglyceride and –cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.

Authors

Kimber L. Stanhope ... Lars Berglund, Peter J. Havel

×

Total citations by year in Crossref

Year: 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 15 60 52 37 40 32 11 247
Citation information

Citations to this article in Crossref (247)

Title and authors Publication Year
Qualitative aspects of diet affecting visceral and subcutaneous abdominal adipose tissue: a systematic review of observational and controlled intervention studies
K Fischer, JA Pick, D Moewes, U Nothlings
Nutrition Reviews 2015
Dietary Adequacy among Rural Yup’ik Women in Western Alaska
S Sharma, E Mead, D Simeon, G Ferguson, F Kolahdooz
Journal of the American College of Nutrition 2015
La mayor adherencia a un patrón de dieta mediterránea se asocia a una mejora del perfil lipídico plasmático: la cohorte del Aragon Health Workers Study
JL Peñalvo, B Oliva, M Sotos-Prieto, I Uzhova, B Moreno-Franco, M León-Latre, JM Ordovás
Revista Española de Cardiología 2015
Managing and Preventing Obesity
BM Popkin, GA Bray, F Hu
Managing and Preventing Obesity 2015
Roles of diets and dietary factors in the pathogenesis, management and prevention of abnormal serum uric acid levels
CE Ekpenyong, N Daniel
PharmaNutrition 2015
A novel gene network analysis in liver tissues of diabetic rats in response to resistant starch treatment
Z Wang, Y Zhang, R Shi, Z Zhou, F Wang, P Strappe
SpringerPlus 2015
Greater Adherence to a Mediterranean Dietary Pattern Is Associated With Improved Plasma Lipid Profile: the Aragon Health Workers Study Cohort
JL Peñalvo, B Oliva, M Sotos-Prieto, I Uzhova, B Moreno-Franco, M León-Latre, JM Ordovás
Revista Española de Cardiología (English Edition) 2015
Added Fructose
JJ DiNicolantonio, JH O'Keefe, SC Lucan
Mayo Clinic Proceedings 2015
Comparison of the effect of post-heparin and pre-heparin lipoprotein lipase and hepatic triglyceride lipase on remnant lipoprotein metabolism
T Shirakawa, K Nakajima, Y Shimomura, J Kobayashi, K Stanhope, P Havel, T Machida, H Sumino, M Murakami
Clinica Chimica Acta 2015
Determination of serum lipoprotein lipase using a latex particle-enhanced turbidimetric immunoassay with an automated analyzer
T Machida, K Miyashita, T Sone, S Tanaka, K Nakajima, M Saito, K Stanhope, P Havel, H Sumino, M Murakami
Clinica Chimica Acta 2015
PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation
E Barroso, R Rodríguez-Rodríguez, MR Chacón, E Maymó-Masip, L Ferrer, L Salvadó, E Salmerón, M Wabistch, X Palomer, J Vendrell, W Wahli, M Vázquez-Carrera
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2015
Catechin and quercetin attenuate adipose inflammation in fructose-fed rats and 3T3-L1 adipocytes
MA Prieto, A Bettaieb, CR Lanzi, VC Soto, DJ Perdicaro, CR Galmarini, FG Haj, RM Miatello, PI Oteiza
Molecular Nutrition & Food Research 2015
Maternal taurine supplementation attenuates maternal fructose-induced metabolic and inflammatory dysregulation and partially reverses adverse metabolic programming in offspring
M Li, CM Reynolds, DM Sloboda, C Gray, MH Vickers
The Journal of Nutritional Biochemistry 2015
IRE1 impairs insulin signaling transduction of fructose-fed mice via JNK independent of excess lipid
RQ Sun, H Wang, XY Zeng, SM Chan, SP Li, E Jo, SL Leung, JC Molero, JM Ye
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2015
The Paradox of Artificial Sweeteners in Managing Obesity
JR Roberts
Current Gastroenterology Reports 2015
Obesity--a disease with many aetiologies disguised in the same oversized phenotype: has the overeating theory failed?
P Stenvinkel
Nephrology Dialysis Transplantation 2014
CardioPulse Articles * Translational research and 'blue skies' mentality brings rewards * Metabolite profiles and the risk of cardiometabolic disease * Passive smoking causes irreversible damage to children's arteries * Should dental health now be considered a marker of coronary heart disease? * The effects of diet or bariatric surgery on cardiac function * Discarded surgery fat to treat myocardial infarction? * Sugar-sweetened beverages and cardiovascular diseases
European Heart Journal 2014
Consumption of highly processed snacks, sugar-sweetened beverages and child feeding practices in a rural area of Nicaragua: Child feeding practices in rural Nicaragua
M Contreras, EZ Blandón, LÅ Persson, EC Ekström
Maternal & Child Nutrition 2014
Short-term dietary supplementation with fructose accelerates gastric emptying of a fructose but not a glucose solution
AM Yau, J McLaughlin, RJ Maughan, W Gilmore, GH Evans
Nutrition 2014
Effects of green tea catechins on nonalcoholic steatohepatitis (NASH) patients
Y Fukuzawa, MP Kapoor, K Yamasaki, T Okubo, Y Hotta, LR Juneja
Journal of Functional Foods 2014
Fructose Containing Sugars Do Not Raise Blood Pressure or Uric Acid at Normal Levels of Human Consumption
TJ Angelopoulos, J Lowndes, S Sinnett, JM Rippe
Journal of Clinical Hypertension 2014
Association between sugar-sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and dose–response meta-analysis of prospective studies
DC Greenwood, DE Threapleton, CE Evans, CL Cleghorn, C Nykjaer, C Woodhead, VJ Burley
British Journal of Nutrition 2014
Comparison of Eating Habits in Obese and Non-obese Filipinas Living in an Urban Area of Japan
CH Oh, E Saito
Journal of Immigrant and Minority Health 2014
Review of the role of refined dietary sugars (fructose and glucose) in the genesis of retinal disease: Refined sugars in retinal disease
FM Kearney, XJ Fagan, S Al-Qureshi
Clinical & Experimental Ophthalmology 2014
Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease
JE Lambert, MA Ramos–Roman, JD Browning, EJ Parks
Gastroenterology 2014

Advertisement
Advertisement