Advertisement

Citations to this article

Abstract

Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle–triglyceride and –cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.

Authors

Kimber L. Stanhope ... Lars Berglund, Peter J. Havel

×

Total citations by year in Crossref

Year: 2014 2013 2012 2011 2010 2009 Total
Citations: 59 72 52 53 41 15 292
Citation information

Citations to this article in Crossref (292)

Title and authors Publication Year
The potential for a carbon stable isotope biomarker of dietary sugar intake
AH Jahren, JN Bostic, BM Davy
Journal of Analytical Atomic Spectrometry 2014
Fatty acid sources and their fluxes as they contribute to plasma triglyceride concentrations and fatty liver in humans:
MM Jacome-Sosa, EJ Parks
Current Opinion in Lipidology 2014
Immunonutrition: Interactions of Diet, Genetics, and Inflammation
Z Li, D Heber
Immunonutrition: Interactions of Diet, Genetics, and Inflammation 2014
Fructose promotes the differentiation of 3T3-L1 adipocytes and accelerates lipid metabolism
B Legeza, Z Balázs, A Odermatt
FEBS Letters 2014
Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease
JE Lambert, MA Ramos–Roman, JD Browning, EJ Parks
Gastroenterology 2014
Review of the role of refined dietary sugars (fructose and glucose) in the genesis of retinal disease: Refined sugars in retinal disease
FM Kearney, XJ Fagan, S Al-Qureshi
Clinical & Experimental Ophthalmology 2014
Laparoscopic greater curvature plication: Surgical techniques and early outcomes of a Chinese experience
D Shen, H Ye, Y Wang, Y Ji, X Zhan, J Zhu
Surgery for Obesity and Related Diseases 2014
Acute intake of a high-fructose diet alters the balance of adipokine concentrations and induces neutrophil influx in the liver
DF Rodrigues, MC Henriques, MC Oliveira, Z Menezes-Garcia, PE Marques, DG Souza, GB Menezes, MM Teixeira, AV Ferreira
The Journal of Nutritional Biochemistry 2014
(−)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress
A Bettaieb, MA Prieto, CR Lanzi, RM Miatello, FG Haj, CG Fraga, PI Oteiza
Free Radical Biology and Medicine 2014
Obesity and lifespan health--importance of the fetal environment
AF Tarantal, L Berglund
Nutrients 2014
Caloric beverage drinking patterns are differentially associated with diet quality and adiposity among Spanish girls and boys
H Schröder, MA Mendez, L Ribas, AN Funtikova, SF Gomez, M Fíto, J Aranceta, L Serra-Majem
European Journal of Pediatrics 2014
Effects of chronic intake of starch-, glucose- and fructose-containing diets on eating behaviour in adult minipigs
M Ochoa, CH Malbert, JP Lallès, E Bobillier, D Val-Laillet
Applied Animal Behaviour Science 2014
Changes in waist circumference relative to body mass index in Chinese adults, 1993–2009
D Stern, LP Smith, B Zhang, P Gordon-Larsen, BM Popkin
International Journal of Obesity 2014
Misconceptions about fructose-containing sugars and their role in the obesity epidemic
VJ van Buul, L Tappy, FJ Brouns
Nutrition Research Reviews 2014
The cardiometabolic benefits of glycine: Is glycine an 'antidote' to dietary fructose?
MF McCarty, JJ DiNicolantonio
Open Heart 2014
Prevention and management of type 2 diabetes: dietary components and nutritional strategies
SH Ley, O Hamdy, V Mohan, FB Hu
The Lancet 2014
Effects of green tea catechins on nonalcoholic steatohepatitis (NASH) patients
Y Fukuzawa, MP Kapoor, K Yamasaki, T Okubo, Y Hotta, LR Juneja
Journal of Functional Foods 2014
Diets and nonalcoholic fatty liver disease: The good and the bad
M Asrih, FR Jornayvaz
Clinical Nutrition 2014
Liquid fructose down-regulates liver insulin receptor substrate 2 and gluconeogenic enzymes by modifying nutrient sensing factors in rats
A Rebollo, N Roglans, M Baena, A Padrosa, RM Sánchez, M Merlos, M Alegret, JC Laguna
The Journal of Nutritional Biochemistry 2014
Short-term dietary supplementation with fructose accelerates gastric emptying of a fructose but not a glucose solution
AM Yau, J McLaughlin, RJ Maughan, W Gilmore, GH Evans
Nutrition 2014
Nutrition in the Prevention and Treatment of Abdominal Obesity
E Suliga
Nutrition in the Prevention and Treatment of Abdominal Obesity 2014
Non-alcoholic fatty liver disease in patients with diabetes mellitus
SR Naini, M Fuchs
Expert Review of Endocrinology & Metabolism 2014
The effects of nutrition-induced abnormal food metabolism in the Southern Plains woodrat ( Neotoma micropus ): comparisons of variations of the Western diet
DM Post, BL Hawkins, JA Eldridge
Journal of Animal Physiology and Animal Nutrition 2014
Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy
S Kume, D Koya, T Uzu, H Maegawa
BioMed Research International 2014
HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets
Z Khitan, M Harsh, K Sodhi, JI Shapiro, NG Abraham
Journal of nutrition and metabolism 2014

Advertisement
Advertisement