Citations to this article


Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle–triglyceride and –cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.


Kimber L. Stanhope ... Lars Berglund, Peter J. Havel


Total citations by year in Crossref

Year: 2014 2013 2012 2011 2010 2009 Total
Citations: 48 64 44 44 35 12 247
Citation information

Citations to this article in Crossref (247)

Title and authors Publication Year
Immunonutrition: Interactions of Diet, Genetics, and Inflammation
Z Li, D Heber
Immunonutrition: Interactions of Diet, Genetics, and Inflammation 2014
Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis
CC Duwaerts, JJ Maher
Current Hepatology Reports 2014
Nutrition in the Prevention and Treatment of Abdominal Obesity
E Campbell, A Schlappal, E Geller, TW Castonguay
Nutrition in the Prevention and Treatment of Abdominal Obesity 2014
Weight classification does not influence the short-term endocrine or metabolic effects of high-fructose corn syrup-sweetened beverages
TD Heden, Y Liu, ML Kearney, JA Kanaley
Applied Physiology, Nutrition, and Metabolism 2014
Fructose promotes the differentiation of 3T3-L1 adipocytes and accelerates lipid metabolism
B Legeza, Z Balázs, A Odermatt
FEBS Letters 2014
Hypercaloric diets with increased meal frequency, but not meal size, increase intrahepatic triglycerides: A randomized controlled trial: KOOPMAN ET AL
KE Koopman, MW Caan, AJ Nederveen, A Pels, MT Ackermans, E Fliers, SE la Fleur, MJ Serlie
Hepatology 2014
Nonalcoholic fatty liver disease and bariatric surgery in adolescents
AX Holterman, J Gurria, S Tanpure, N DiSomma
Seminars in Pediatric Surgery 2014
Obesity and the Liver: Nonalcoholic fatty liver disease
SW Koppe
Translational Research 2014
Acute responses of regional vascular conductance to oral ingestion of fructose in healthy young humans
MY Endo, C Fujihara, C Yamazaki, H Kashima, K Eguchi, A Miura, Y Fukuoka, Y Fukuba
Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats
QY Zhang, Y Pan, R Wang, LL Kang, QC Xue, XN Wang, LD Kong
The Journal of Nutritional Biochemistry 2014
Laparoscopic greater curvature plication: Surgical techniques and early outcomes of a Chinese experience
D Shen, H Ye, Y Wang, Y Ji, X Zhan, J Zhu
Surgery for Obesity and Related Diseases 2014
Dietary carbohydrates and intestinal lipoprotein production:
C Morgantini, C Xiao, S Dash, GF Lewis
Current Opinion in Clinical Nutrition and Metabolic Care 2014
Handbook of Obesity: Epidemology, Etiology, and Physiopathology
S Chiu, R Krauss
Handbook of Obesity: Epidemology, Etiology, and Physiopathology 2014
Today's and yesterday's of pathophysiology: Biochemistry of metabolic syndrome and animal models
S Aydin, A Aksoy, S Aydin, M Kalayci, M Yilmaz, T Kuloglu, C Citil, Z Catak
Nutrition 2014
Changes in waist circumference relative to body mass index in Chinese adults, 1993–2009
D Stern, LP Smith, B Zhang, P Gordon-Larsen, BM Popkin
International Journal of Obesity 2014
Misconceptions about fructose-containing sugars and their role in the obesity epidemic
VJ van Buul, L Tappy, FJ Brouns
Nutrition Research Reviews 2014
The cardiometabolic benefits of glycine: Is glycine an 'antidote' to dietary fructose?
MF McCarty, JJ DiNicolantonio
Open Heart 2014
Silymarin ameliorates fructose induced insulin resistance syndrome by reducing de novo hepatic lipogenesis in the rat
P Prakash, V Singh, M Jain, M Rana, V Khanna, MK Barthwal, M Dikshit
European Journal of Pharmacology 2014
Association between sugar-sweetened and artificially sweetened soft drinks and type 2 diabetes: systematic review and dose–response meta-analysis of prospective studies
DC Greenwood, DE Threapleton, CE Evans, CL Cleghorn, C Nykjaer, C Woodhead, VJ Burley
British Journal of Nutrition 2014
Effects of green tea catechins on nonalcoholic steatohepatitis (NASH) patients
Y Fukuzawa, MP Kapoor, K Yamasaki, T Okubo, Y Hotta, LR Juneja
Journal of Functional Foods 2014
Diets and nonalcoholic fatty liver disease: The good and the bad
M Asrih, FR Jornayvaz
Clinical Nutrition 2014
Sugar-sweetened beverage intake in relation to semen quality and reproductive hormone levels in young men
YH Chiu, MC Afeiche, AJ Gaskins, PL Williams, J Mendiola, N Jorgensen, SH Swan, JE Chavarro
Human Reproduction 2014
Short-term dietary supplementation with fructose accelerates gastric emptying of a fructose but not a glucose solution
AM Yau, J McLaughlin, RJ Maughan, W Gilmore, GH Evans
Nutrition 2014
Nutrition in the Prevention and Treatment of Abdominal Obesity
E Suliga
Nutrition in the Prevention and Treatment of Abdominal Obesity 2014
Exercise and Dietary-Mediated Reductions in Postprandial Lipemia
EP Plaisance, G Fisher
Journal of nutrition and metabolism 2014