PPARγ in the endothelium regulates metabolic responses to high-fat diet in mice
J. Clin. Invest. 119:1 doi:10.1172/JCI36233 [Go to this article.]

Figure 3
Tie2Cre-mediated PPARγ deletion improves glucose control and insulin sensitivity in response to high-fat diet.

(A) Fasting glucose and (B) insulin levels and (C) glucose tolerance and (D) insulin tolerance testing in γEC/BM-KO and γEC/BM-WT mice after standard chow or high-fat diet (n = 5–6). (C) The AUC of glucose levels during glucose tolerance tests is shown. *P < 0.05, **P < 0.01 versus obese γEC/BM-WT mice. GTT, glucose tolerance test.