Figure 7
Myocardial lipid accumulation and mitochondrial dysfunction in
Hdac3cko mice.
(A) Increased triglycerides in Hdac3cko hearts after fasting. Triglycerides were extracted from wild-type and Hdac3cko hearts at 8 weeks and quantified. (B) Oil red O staining of 8-week-old wild-type mice and cardiac deletion of Hdac3 following a 24-hour fast. Red droplets indicate neutral lipids. Hdac3cko mice show substantial lipid accumulation. (C) Hdac3cko hearts show impaired mitochondrial function. Complex I activity, NADH oxidase activity, and free radicals were determined from 8-week-old wild-type and Hdac3cko mice.
