Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?
J. Clin. Invest. Frank Kirchhoff, et al. 118:1622 doi:10.1172/JCI35487 [Go to this article.]

Figure 2
Nef-mediated suppression of the clonogenic potential of HSCs. (A) HSC clonogenic potential is dependent on transcriptional activation of STAT5A/B. (B) As reported in the current study by Prost et al. (14), in the setting of HIV and SIVmac infection, Nef induces upregulation of PPARγ, which in turn suppresses the transcription of STAT5A/B, thus causing a reduction of the function and clonogenic potential of HSCs.