Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells
J. Clin. Invest. Paolo Monti, et al. 118:1806 doi:10.1172/JCI35197 [Go to this article.]

Figure 1
Reduction of blood lymphocyte counts following islet transplantation. (A) Total blood lymphocyte counts (mean ± SEM) from 13 patients who received islet transplantation with anti–IL-2R induction plus rapamycin and FK506 maintenance therapy. Results are shown for the first 30 d after the first islet infusion and after the second islet infusion in patients who received 2 or more infusions (n = 11). *P < 0.05, ^#P < 0.01, ^ΧP < 0.001 versus pretransplant. (B) A single representative case (patient hSR-058-ITA-Ed08 per standard Edmonton protocol) in whom sequential counts for CD3⁺ T cells, CD4⁺ T cells, CD8⁺ T cells, and CD19⁺ B cells are shown.