DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
J. Clin. Invest. Lisiane B. Meira, et al. 118:2516 doi:10.1172/JCI35073 [
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Figure 2Aag–/– animals are more susceptible than
Aag+/+ animals to DSS-induced colitis.
(
A) Change in colon length. (
B) Spleen weight as a percentage of body weight. AOM+DSS
Aag+/+,
n = 14; AOM+DSS
Aag–/–,
n = 31; AOM
Aag+/+,
n = 15; AOM
Aag–/–,
n = 19; DSS
Aag+/+,
n = 10; DSS
Aag–/–,
n = 10. Data are mean ± SD. (
C) Histopathology scores for severity of inflammation, epithelial defects, and crypt atrophy. A description of the histopathological endpoints for inflammation examined can be found in Supplemental Methods. Epithelial defect scores were based on increased gland dilation and surface epithelial attenuation. (
D) Photomicrographs showing a DSS-treated
Aag+/+ colon bearing a lesion with an average epithelial defect score (left) and a DSS-treated
Aag–/– colon bearing a lesion with an average epithelial defect score (right). Scale bars: 100 μm.
