Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice
J. Clin. Invest. Shingo Matsumoto, et al. 118:1965 doi:10.1172/JCI34928 [
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Figure 2EPR oxygen imaging of normal muscle in live mice. EPRI method allows the pO
2 map from deep in tissue of healthy mouse to be obtained. The anatomic image from MRI (
A) of the lower body of a healthy mouse (without tumor bearing) and corresponding pO
2 map from EPRI (
B) showed that the normal muscle region had relatively homogeneous pO
2 distribution. The anatomic image (
C) and pO
2 image (
D) were also obtained from the contra-lateral normal leg of a SCC tumor-bearing mouse, and compared with that of a healthy mouse. (
E) There was no significant difference in pO
2 between normal muscle tissues with or without tumor bearing as opposed to the significant, lower pO
2 in tumor region of the SCC mouse.
