Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
J. Clin. Invest. 118:9 doi:10.1172/JCI34739 [Go to this article.]

Figure 6
MAPK pathway pharmacological blockade increases rapamycin-mediated growth inhibition in vitro.

(A and B) Effect of rapamycin (Rapa; 20 nM), UO126 (10 μM), or the combination of both on cell growth (A) and BrdU incorporation (B; after 24 hours of treatment; n = 4). **P < 0.01 compared with vehicle-treated cells; ^#P < 0.05 and ^##P > 0.01 compared with rapamycin-treated cells; ^$P < 0.05 and ^$$P < 0.01 compared with UO126-treated cells. Error bars indicate SD.