Figure 2
Mean tissue iduronidase in nontolerant MPS I dogs receiving 0.58 mg/kg i.v. ERT, the current standard of care (
A) was compared with that achieved with induction of immune tolerance, increased dose, or both (
B–
D) (expressed as percent change).
Percent change in mean tissue iduronidase levels in tolerant MPS I dogs receiving 0.58 mg/kg i.v. ERT (B), nontolerant MPS I dogs receiving 2 mg/kg i.v. ERT (C), and tolerant MPS I dogs receiving 2 mg/kg i.v. ERT (D). Percent change is measured against mean iduronidase levels in nontolerant MPS I dogs treated with the clinically used 0.58-mg/kg i.v. ERT (A). *P < 0.05, statistically significant versus nontolerant, 0.58 mg/kg/wk.
