A mouse model for Costello syndrome reveals an Ang II–mediated hypertensive condition
J. Clin. Invest. Alberto J. Schuhmacher, et al. 118:2169 doi:10.1172/JCI34385 [
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Figure 5Heart and kidney defects in H-
RasG12V mice.
(
A) Formalin-fixed hearts. (
B) H&E-stained heart ventricular sections. Interventricular wall (IV), LV, and RV are indicated. (
C) Fibrosis in the LV, as shown by Sirius red–stained preparations. (
D) H&E-stained aortic valves (arrowheads). (
E) H&E-stained aorta media wall (asterisks). (
F) Kidney fibrosis, as shown by Sirius red–stained preparations. Scale bars: 1 mm (
A and
B); 50 μm (
D); 100 μm (
C,
E, and
F).
