Helicobacter pylori induces β3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl–Lewis x
J. Clin. Invest. Nuno T. Marcos, et al. 118:2325 doi:10.1172/JCI34324 [Go to this article.]

Figure 7
Schematic representation of the biosynthesis of Neo-lactoseries and terminal glycosylation. The β3GnT5 is essential for the synthesis of type 2 chains on glycolipids. The glycan chain it generates, GlcNAc-LacCer, is a substrate for a β4Gal-T that forms the type 2 chain, which may be further substituted by sialyltransferases and fucosyltransferases completing the biosynthesis of various Lewis antigens, including the sialyl-Le^x antigen. The action of other glycosyltransferases may also lead to termination of the chain with the formation of histo-blood groups H, A, and B. Alternatively, the type 2 chain may also be extended by the action of iGnT, leading to the biosynthesis polylactosamines, formation of polymeric Lewis antigens, and termination of the chain.