A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy
J. Clin. Invest. Anja Fritsch, et al. 118:1669 doi:10.1172/JCI34292 [Go to this article.]

Figure 5
Mitten deformities in the extremities of the Col7a1^flNeo/flNeo mice closely resemble severe human RDEB. (A–C) Hands in human RDEB patients at 2.5 years (A), 6.5 years (B), and 7.5 years of age (C). (D–G) Fore paws of Col7a1^flNeo/flNeo mice were documented at 17 days (D), 60 days (E), and 80 days of age (F and G). The clinical phenotypes in RDEB patients and in Col7a1^flNeo/flNeo mice developed in a similar manner.