The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells
J. Clin. Invest. Godwin Nchinda, et al. 118:1427 doi:10.1172/JCI34224 [Go to this article.]

Figure 3
Targeted vaccination induces enhanced antibody responses. Antigen-specific antibody titers were determined for each mouse in a group (n = 5) from serum harvested at 3 or 5 weeks after vaccination with the indicated doses of DNA. (A) Titers of anti-OVA–specific isotype in B6 mice after 1 immunization with graded doses of DNA vaccine i.m. in combination with electroporation. (B) Titers of anti-HIV gag p41 isotypes in BALB/c mice after 1 immunization with low doses of DNA vaccine i.m. in combination with electroporation. DNA vaccine type is displayed at the top. Antibody titers are expressed as group mean ± SD. Results are representative of 3 experiments.