HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse
J. Clin. Invest. Kathleen A. Connell, et al. 118:1050 doi:10.1172/JCI34193 [
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Figure 3HOXA11 mRNA and protein expression in the USLs of women with and without POP.
(
A)
HOXA11 expression in USLs shown by immunohistochemistry. Original magnification, ×60. Note the strong
HOXA11 expression in the USLs of a premenopausal subject with normal pelvic support compared with the weak expression of
HOXA11 in the USLs of a subject with POP. (
B) Comparison of mRNA expression of
HOXA11 in USLs in women with and without POP. Expression of
HOXA11 was dramatically reduced in women with POP versus controls (
P < 0.01).
