Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5
J. Clin. Invest. Wenbin Xiao, et al. 118:924 doi:10.1172/JCI34013 [
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Figure 1Severe lung inflammation characterized by extensive infiltration with M2-type macrophages in Lyn/Hck-deficient mice. (
A) Growth of dko mice was slower than WT mice. The mice shown are 8 weeks in age. Data represent mean ± SD throughout the figures. (
B) Gross appearance showed that lungs are consolidated in dko mice. (
C and
D) Microscopic examination showed abundant M2 macrophages in alveoli of dko lungs. Original magnification, ×100 (H&E); others, ×400 (
C). Arrows indicate crystals. (
E) A crystal recovered from BAL from dko mice and illuminated by green light of 488 nm (original magnification, ×400). (
F) Increased numbers of macrophages (Mφ) were recovered in BAL fluids of dko mice. (
G) Ym-1–positive cells were increased in BAL macrophages from dko mice.
