Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans
J. Clin. Invest. Hiroshi Watanabe, et al. 118:2260 doi:10.1172/JCI33891 [Go to this article.]

Figure 1
Structure of β1 and β1B subunits. (A) Genomic structure of SCN1B. (B) Extension of exon 3 (c.208–458) into intron 3 creates a novel 3′ end of the transcript (exon 3A, c.208–978) and generates an alternate transcript encoding β1B. The gray region indicates the unique sequence of exon 3A. (C) Predicted topology of β1 and β1B. The β1B protein has unique juxtamembrane, transmembrane, and intracellular domains. The arrow indicates the initial amino acid of the β1B-specific segment. Circles indicate the locations of the mutations.