Complex two-gene modulation of lung disease severity in children with cystic fibrosis
J. Clin. Invest. Ruslan Dorfman, et al. 118:1040 doi:10.1172/JCI33754 [
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Figure 1Normalized MBL2 levels corresponding to 6
MBL2 gene diplotypes (**00, XYA0, YYA0, XXAA, XYAA, and YYAA) in CF patient and parent cohorts.
(
A and
B) Distribution of normalized MBL2 expression values and median MBL2 expression values for each diplotype is shown for 600 parents (
A) and 1,393 PI CF patients (
B). (
C and
D) Comparison of normalized MBL2 expression values between patients and parents (
C) and between 848 pediatric and 545 adult patients (
D). Statistical difference was tested using the Wilcoxon rank-sum test. *
P < 0.05; **
P < 0.01; ***
P < 0.001; ****
P < 0.0001.
