Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis
J. Clin. Invest. Kirsteen H. Maclean, et al. 118:79 doi:10.1172/JCI33700 [Go to this article.]

Figure 1
CQ prevents Myc-induced lymphomagenesis. (A) Administration (i.p.) of CQ impairs lymphoma development in Eμ-Myc transgenic mice. Beginning at weaning, Eμ-Myc mice were treated with 3.5 mg/kg CQ (in PBS) i.p. every 5 days, or with PBS alone (n = 18 for each group). Median survival time was 98 days for mice treated with PBS versus 265 days for mice receiving CQ (P = 0.0002). (B) CQ treatment prevents lymphocytosis in precancerous Eμ-Myc transgenic mice. Beginning at 4 weeks, Eμ-Myc transgenic mice and their wild-type littermates (n = 5–8 for each group) were injected with 3.5 mg/kg CQ (in PBS) i.p. every 5 days, or with PBS alone. At 7 weeks, mice were then analyzed for wbc counts. CQ had no effect on wbc numbers in wild-type mice but had profound effects on wbc numbers in Eμ-Myc mice. *P < 0.05. (C) CQ treatment prevents splenomegaly in precancerous Eμ-Myc transgenic mice. Beginning at 4 weeks, Eμ-Myc transgenic mice and their wild-type littermates (n = 8 for each group) were injected with 3.5 mg/kg CQ (in PBS) i.p. every 5 days, or injected with PBS alone. At 7 weeks, mice were then analyzed for spleen weight. Pictures in inset show representative spleens from wild-type and Eμ-Myc transgenic mice injected with PBS or CQ.