Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome
J. Clin. Invest. Michael Brunner, et al. 118:2246 doi:10.1172/JCI33578 [
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Figure 7APD and APD dispersion in transgenic rabbits. (
A–
C) Typical raw data of action potential traces are shown in the left columns. APDs were measured as described in Methods and mapped in each group. Isochronal lines were drawn every 5 ms with lighter color representing shorter APD. (
D) Mean APD in each group at basic cycle length of 350 and 300 ms. LMC (
n = 6), LQT1 (
n = 3), and LQT2 rabbits (
n = 4). LQT2 and LQT1 rabbits show statistically significant differences in APD compared with LMC; *
P < 0.05. (
E) APD dispersion. APD dispersion was calculated by differences between APD
max and APD
min. LQT2 rabbits show greater dispersion compared with LMC.
†P < 0.05.
