Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome
J. Clin. Invest. Michael Brunner, et al. 118:2246 doi:10.1172/JCI33578 [
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Figure 2Phenotypic characterization in sedated animals. (
A) Sample ECGs (lead II) of the founders and an LMC rabbit with midazolam sedation (2 mg/kg, i.m.). Note the markedly prolonged QT interval and the lack of an isoelectric T-P line in both transgenic rabbits. (
B) QT/RR relationship (mean of all 12 leads per animal) under midazolam sedation in the 2 founder rabbits and 6 LMCs. Dotted lines denote the 95% confidence intervals of the linear regression derived from the LMCs. (
C) RR and QT intervals (mean of 12-lead surface ECG per animal) in ketamine/xylazine-sedated male rabbits (
n = 13 LMC, 9 LQT1, and 10 LQT2 animals). (
D) Effect of isoproterenol on QT index in isoflurane-sedated LMC, LQT1, and LQT2 rabbits. Solid bars denote baseline (base); hatched bars denote isoproterenol (Iso). **
P < 0.01.
