α3β1 integrin–controlled Smad7 regulates reepithelialization during wound healing in mice
J. Clin. Invest. Louise E. Reynolds, et al. 118:965 doi:10.1172/JCI33538 [
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Figure 1Reepithelialization is impaired in
Itga3–/– skin.
Midline sections of WT (
A,
C,
E,
G, and
I) and
Itga3–/– (–/–) (
B,
D,
F,
H, and
J) wounds were stained with H&E for examination of reepithelialization at 0 (
A and
B), 2 (
C and
D), 4 (
E and
F), 7 (
G and
H), and 14 days (
I and
J) after injury. (
K) Quantitation of wound widths. (
L) Quantitation of neoepithelial length. Results represent the mean ± SEM;
n = 11/time point/genotype. *
P ≤ 0.05. Arrows represent the edges of migrating epithelial lips. Scale bars: 750 μm (
A–
D); 375 μm (
E–
J).
