Bim-mediated deletion of antigen-specific CD8⁺ T cells in patients unable to control HBV infection
J. Clin. Invest. A. Ross Lopes, et al. 118:1835 doi:10.1172/JCI33402 [Go to this article.]

Figure 5
Mcl1 and CD127 expression of HBV-specific CD8⁺ T cells. (A) Intracellular staining for Mcl1 in core and envelope-specific CD8⁺ T cells expanded in vitro from individuals with chronic and resolved infection (left) with cumulative data (right). (B) Summary of Mcl1 levels in HBV-specific (H), total (T), and influenza-specific (I) CD8⁺ T cells from individuals with persistent HBV infection. (C) Correlation between viral load and the level of Mcl1 expression in HBV-specific CD8⁺ T responses from individuals with chronic infection (left) and relative levels of Mcl1 expression in resolved and persistently infected patients segregated according to eAg status (right). (D) Intracellular stain for Mcl1 in CD127^hi populations of HBV-specific and total CD8⁺ T cells. Error bars indicate mean ± SD.