Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits
J. Clin. Invest. Lea Scheppke, et al. 118:2337 doi:10.1172/JCI33361 [Go to this article.]

Figure 2
Src kinase antagonists reduce laser-induced retinal vascular permeability. (A–C) Whole-mount fluorescent dextran angiography 3 days after laser treatment. Ischemia is indicated by relatively hypoperfused major retinal vessels (arrows, A). Vascular leakage in laser-treated eyes is indicated by bright background fluorescence (A) and by perivascular staining and leakage of tracer (B and inset, tracer green, vessels labeled red with isolectin). (C) SKI-606 treatment partly reduced angiographic evidence of vascular exudation in laser-treated eyes. (D) Retinal EB dye accumulation in control and laser-treated eyes; treatment with systemically administered PP1 or SKI-606 reduced laser-induced dye accumulation but did not alter leakage in nonlasered eyes. Error bars indicate SEM. No laser/systemic vehicle injection, 2.47 ± 0.34; laser/vehicle, 11.22 ± 2.03; no laser/SKI-606, 1.67 ± 0.23; laser/SKI-606, 3.69 ± 1.01; no laser/PP1, 2.86 ± 0.38; laser/PP1, 7.34 ± 1.42. Original magnification, ×4 (A); ×10 (inset, ×20) (B, C). *P < 0.05; **P < 0.01.