The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
J. Clin. Invest. Beichu Guo, et al. 118:1680 doi:10.1172/JCI33342 [Go to this article.]

Figure 2
Increased CNS inflammation in TRIF-deficient mice during EAE. Representative sections of lumbar spinal cord from WT and TRIF-deficient mice at day 12 after MOG/CFA immunization were stained with H&E to determine inflammation or immunostained with anti-CD4 or anti–IL-17 for infiltration of CD4⁺ and Th17 cells. Data are representative of 3 experiments with similar results.