The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
J. Clin. Invest. Beichu Guo, et al. 118:1680 doi:10.1172/JCI33342 [Go to this article.]

Figure 1
TRIF-deficient mice develop severe EAE. (A) Mean EAE score and (B) disease incidence in WT mice (n = 12) and TRIF^Lps2/Lps2 mice (n = 12) at each time point. WT and TRIF-deficient mice were immunized with MOG peptide (MOG_35–55) emulsified in CFA. Mice were assigned a disease score of 0 to 5 based on the severity of EAE.