A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI
J. Clin. Invest. Constantin von zur Muhlen, et al. 118:1198 doi:10.1172/JCI33314 [Go to this article.]

Figure 5
3D data and MRI signal quantification of animals with intracerebral TNF injection. (A) LIBS-MPIO binding pattern after intracerebral TNF-injection in a 3D reconstruction, showing the enhancement of cortical and central LIBS-MPIO binding. (B) Minimal background binding was observed in animals with control-MPIO injection. (C) Quantitative analysis showed significantly higher binding of LIBS-MPIO to TNF-injected brain areas compared with all controls.