A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI
J. Clin. Invest. Constantin von zur Muhlen, et al. 118:1198 doi:10.1172/JCI33314 [Go to this article.]

Figure 3
Data from animals with CM and LIBS-MPIO contrast agent injection. (A and B) T₂-weighted 3D gradient-echo images from CM mice following intravenous injection of LIBS-MPIO (A) and control-MPIO (B) are presented in 2 representative slices at 2 different levels within the same brain. Areas of MPIO-induced signal appeared as dark signal voids (arrows) in cortical regions of the LIBS-MPIO–injected mouse, but not in the control-MPIO–injected mouse. (C and D) 3D reconstruction confirmed the cortical binding pattern in the LIBS-MPIO–injected mouse (C), whereas only modest background binding was evident in the control-MPIO animal (D). (E) Quantification of signal voids demonstrated a significant difference between the LIBS-MPIO– and control-MPIO–injected animals.