A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI
J. Clin. Invest. Constantin von zur Muhlen, et al. 118:1198 doi:10.1172/JCI33314 [
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Figure 1Conventional imaging of murine CM. (
A) Coronal T
1-weighted image acquired 7 days after the injection of 10
6 P. berghei ANKA–parasitized rbcs. (
B) T
1-weighted image from the same animal following injection of Gd-DTPA. Note the regions of increased signal intensity compared with
A, indicating blood-brain barrier breakdown (arrow). (
C) T
2-weighted image of the same slice showing increased signal intensity in the same regions as the Gd-DTPA enhancement. (
D) Significant elevation in T
2 in the hippocampi of day-7 terminal-stage CM mice (
P < 0.05).
