Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney
J. Clin. Invest. 118:7 doi:10.1172/JCI33293 [Go to this article.]

Figure 4
High glucose level–induced renin release in GPR91^+/+ and GPR91^–/– mice.

Effects of high glucose level (25.5 mM) on renin release, measured by the reduction in quinacrine fluorescence. Hyperosmotic control using mannitol is also shown (same data as in Figure 1C). C, control baseline renin release. GPR91^+/+ (WT, n = 6) and GPR91^–/– (KO, n = 4) mice were used. *P < 0.001, control vs. high glucose lumen (rabbit, mouse).