The transcription factor IFN regulatory factor–4 controls experimental colitis in mice via T cell–derived IL-6
J. Clin. Invest. Jonas Mudter, et al. 118:2415 doi:10.1172/JCI33227 [
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Figure 3Attenuation of TNBS-induced colitis in IRF4-deficient mice. (
A) IRF4-deficient mice and WT control mice were treated by intrarectal administration of the hapten reagent TNBS followed by monitoring of body weight. TNBS-treated
IRF4–/– mice lost significantly (
P < 0.05) less weight as compared with WT mice. One representative experiment out of 3 is shown. Endoscopic (
B and
C) and histologic (
D and
E) analyses showed significantly reduced inflammation in TNBS-treated
IRF4–/– mice as compared with TNBS-treated WT mice. *
P < 0.05; **
P < 0.01. Data are given as mean values ± SEM (
IRF4+/+ plus TNBS,
n = 17;
IRF4–/– plus TNBS,
n = 14;
IRF4+/+,
n = 8;
IRF4–/–,
n = 11). Data were pooled from 3 independent experiments. Original magnification, ×100.
