The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats
J. Clin. Invest. Tatsuya Morimoto, et al. 118:868 doi:10.1172/JCI33160 [Go to this article.]

Figure 5
DS rats at the age of 11 weeks were randomly assigned to daily oral treatment with curcumin (50 mg/kg/d) or vehicle (1% gum arabic) for 7 weeks. Echocardiographic studies were performed at the age of 11 (before treatment) and 18 weeks (after treatment). (A) Representative photographs of M-mode images from vehicle- and curcumin-treated DS rats at the age of 18 weeks. (B–G) Values are mean ± SEM from 6 rats in the curcumin group and 8 rats in the vehicle group. *P < 0.05 vs. vehicle group. (B) LVEDD. (C) FS. (D) PWT, posterior wall thickness. (E) Body weight. (F) BP. (G) HR, heart rate. (H and I) Values are mean ± SEM from 3 rats in each DR group, 8 rats in the vehicle-treated DS group, and 6 rats in the curcumin-treated DS group.