Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization
J. Clin. Invest. Debanjan Chakroborty, et al. 118:1380 doi:10.1172/JCI33125 [Go to this article.]

Figure 5
DA inhibited VEGFA-induced mobilization of EPCs from the BM through its D₂ receptors. (A and B) Respective isotype controls. (C–J) Flow cytometric determination of CEPC frequency after completion of DA treatment. rhVEGFA was injected i.p. into normal mice for 5 continuous days. Immediately following VEGFA administration, each mouse received i.p. injection of DA (50 mg/kg body weight) for 5 consecutive days beginning from day 1 of VEGFA administration. CEPC frequency on treatment day 5 after completion of the treatment is represented. (K) Absolute number of EPCs in various groups. Treatment with eticlopride, a DA D₂ receptor antagonist, prior to DA treatment completely abrogated the inhibitory effect of DA. Figures are representative of 4 separate experiments for each group. *P < 0.05.