(A) Schematic diagram of a heart following thoracic aortic banding (TAB). (B) Sections of hearts of approximately 3-month-old wild-type and miR-208^–/– mice are shown following sham operation or TAB for 21 days. High-magnification views of the ventricular wall are shown at the bottom. Trichrome staining identifies fibrosis in blue. Note that hypertrophy and fibrosis are diminished in miR208^–/– mice compared with wild-type following TAB. Scale bars: 2 mm (top); 20 μm (bottom). Reproduced with permission from Science (5).