Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARγ/STAT5 signaling pathway in macaques
J. Clin. Invest. Stéphane Prost, et al. 118:1765 doi:10.1172/JCI33037 [Go to this article.]

Figure 4
SIV impairs LTC-IC. The left panel shows LTC-IC assay of CD34⁺ BM cells from 5 uninfected and 5 SIV-infected macaques. Various numbers of progenitor cells were initially seeded as indicated. The right panel shows LTC-IC assay of CD34⁺ BM cells from 5 control animals that were preincubated for 48 hours with plasma from noninfected animals supplemented with SIVmac251 (SIV), BK28-41ΔNef (SIVΔ) (1 × 10² infectious particles/ml), or rNef (0.15 μM).