Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPARγ/STAT5 signaling pathway in macaques
J. Clin. Invest. Stéphane Prost, et al. 118:1765 doi:10.1172/JCI33037 [Go to this article.]

Figure 3
HIV/SIV-related hematopoietic failure is dependent on a central Pro-rich motif of Nef. (A) CD34⁺ cells from control animals were incubated for 48 hours with rNef (0.15 μM) or the indicated pools of Nef peptides (100 nM). (B) Alternatively, CD34⁺ cells were incubated with either wild-type or mutated (P₇₂, P₇₅, P₇₈) peptide B (100 nM). Cells were then processed for CFC assays.