Leptin inhibits 4-aminopyridine– and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents
J. Clin. Invest. Lin Xu, et al. 118:272 doi:10.1172/JCI33009 [Go to this article.]

Figure 8
Leptin inhibition of CA1 field excitatory postsynaptic potentials (fEPSPs) in mouse hippocampal slices depends on the long form of the leptin receptor. Leptin did not inhibit fEPSPs in hippocampal slices obtained from leptin receptor (Ob-Rb)–deficient db/db mice, but did inhibit fEPSPs in slices from wild-type C57BLKS/J mice. The time course of CA1 fEPSPs after the application of 0.6 nM leptin is indicated by the bar for slices from db/db mice (n = 6 slices, 3 mice) (triangles) and C57BLKS/J mice (n = 10 slices, 3 mice) (squares). Data were analyzed as in Figure 3B.