Leptin inhibits 4-aminopyridine– and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents
J. Clin. Invest. Lin Xu, et al. 118:272 doi:10.1172/JCI33009 [Go to this article.]

Figure 7
Leptin inhibition of CA1 fEPSPs in mouse hippocampal slices depends on JAK2 and PI3K activation. The JAK2 inhibitor AG490 and the PI3K inhibitors LY294002 and wortmannin prevented leptin-induced fEPSP inhibition. Time course of CA1 fEPSP slopes after the application of 0.6 nM leptin as indicated by the bar in slices pretreated for at least 3 hours in 20 μM AG490 (n = 5 slices, 3 mice) (A), 16 μM LY294002 (n = 7 slices, 2 mice) (B), or 50 nM wortmannin (n = 6 slices, 2 mice) (C). Data were analyzed as in Figure 3B.