Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice
J. Clin. Invest. Hong Lu, et al. 118:984 doi:10.1172/JCI32970 [Go to this article.]

Figure 4
Renin inhibition reduced atherosclerotic lesion development without overtly altering cellular composition. (A) Atherosclerotic lesion size was measured on the intimal surface of aortic arches. Triangles represent individual mice; circles represent the mean; error bars denote SEM. *P < 0.0001 versus vehicle; ^#P < 0.01 versus 2.5 mg/kg/d aliskiren. (B) Atherosclerotic lesion size was measured in aortic roots. Data are represented throughout the aorta root, with transitions between the sinus and ascending arch depicted as 0. Filled triangles, PBS vehicle (n = 14); filled inverted triangles, 2.5 mg/kg/d aliskiren (n = 14); open triangles, 25 mg/kg/d aliskiren (n = 15); open inverted triangles, 50 mg/kg/d aliskiren (n = 6). Values are mean ± SEM. (C) Examples of atherosclerotic lesions immunostained for macrophages and smooth muscle cells. Aortic roots were immunostained using rat anti-mouse CD68 (1:200, left), or a rabbit anti–α-SMA (1:200, right). Original magnification, ×200.