Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice
J. Clin. Invest. Hong Lu, et al. 118:984 doi:10.1172/JCI32970 [Go to this article.]

Figure 3
Renin inhibition decreased systolic blood pressure in Ldlr^–/– mice. Systolic blood pressure was measured in Ldlr^–/– mice 1 week prior to pump implantation and during 2, 4, 8, and 12 weeks of drug administration at the indicated doses. Aliskiren was also administered at a dose of 50 mg/kg/d to normal diet–fed Ldlr^+/+ C57BL/6 mice (dotted line). Points represent the mean of weekly observations; error bars denote SEM. *P < 0.0001 versus vehicle; ^#P < 0.0001 versus 2.5 mg/kg/d aliskiren.