Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice
J. Clin. Invest. Hong Lu, et al. 118:984 doi:10.1172/JCI32970 [Go to this article.]

Figure 1
Renin inhibition dose-dependently increased renal renin mRNA abundance. Renin mRNA abundance (renin/18S rRNA ratio) was quantified by real-time PCR (n = 5 per group). mRNA bands by gel electrophoresis are also shown; the lanes were run on the same gel but were noncontiguous. Data are mean ± SEM. *P < 0.0001 versus vehicle; ^#P < 0.0001 versus 2.5 mg/kg/d aliskiren.