Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
J. Clin. Invest. Jennifer W. Hill, et al. 118:1796 doi:10.1172/JCI32964 [
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Figure 6Leptin fails to suppress feeding in
Pik3r1 POMCKO Pik3r2–/– mice.
(
A) Food consumption was measured 3 and 24 hours after leptin administration and compared with food consumption in each animal following saline administration. Values were normalized to kg body weight (
n = 11–15). (
B) Body weight 24 hours after injection in
Pik3r1 POMCKO Pik3r2–/– mice and littermate controls lacking POMC-cre expression. Data are mean ± SEM. *
P = 0.0487, **
P = 0.0022 versus saline-injected controls; Student’s
t test.
