Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
J. Clin. Invest. Jennifer W. Hill, et al. 118:1796 doi:10.1172/JCI32964 [Go to this article.]

Figure 3
Leptin induces a decrease in whole-cell input resistance in POMC neurons. (A) Current-clamp recording from a WT neuron showing decreased voltage deflection and increased action potential frequency after leptin application (100 nM). (B) Current versus voltage (I-V) plot from same WT neuron illustrating a characteristic decrease in input resistance subsequent to leptin application. Shown are responses before (control) and during leptin application. (C) Decreased whole-cell input resistance from the neuron groups examined. P values compared with WT treated with leptin alone are shown.