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Eya4-deficient mice are a model for heritable otitis media
Frederic F.S. Depreux, Keith Darrow, David A. Conner, Roland D. Eavey, M. Charles Liberman, Christine E. Seidman, J.G. Seidman
Published in Volume 118, Issue 2
J Clin Invest. 2008; 118(2):651–658 doi:10.1172/JCI32899
This article Copyright © 2008, The American Society for Clinical Investigation
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Figure 5
Bone and cartilaginous skull tissue anatomy of wild-type (+/+) and Eya4–/– (–/–) newborn mice.

Top (A) and lateral (B) skull views demonstrated no craniofacial abnormalities in mutant or wild-type mice (n = 3 for each genotype), but ventral view (C) showed abnormal fusion of palatal bones (dashed box) in Eya4–/– mice. (D) Higher magnification of palatal bones (C, dashed box) and schematic detailing morphologic abnormalities. Note wide separation between flanking palatal bones (incomplete fusion) in Eya4–/– skulls. Pt, pterygoid bone; m, maxillary shelves; P, palate bone. Scale bar: 1 mm.

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