Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality
J. Clin. Invest. Majed N. Aljamali, et al. 118:1825 doi:10.1172/JCI32878 [
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Figure 3In vivo tests of coagulation. (
A) Blood loss in mFVIIa transgenic HB mice expressing low (HB-Low mFVIIa,
n = 10) or high (HB-High mFVIIa,
n = 8) levels of mFVIIa, compared with HB (
n = 20) and WT (
n = 10) littermates. *
P < 0.05 versus HB. Values are mean ± 1 SD. (
B) Representative cremaster real-time thrombus formation in WT, HB, or HB-mFVIIa (high and low expresser) mice. (
C) FeCl
3 carotid artery injury in WT, HB, or HB-mFVIIa (high and low expresser) mice. The single asterisk denotes the time at which the FeCl
3 patch was applied; the double asterisk denotes vessel occlusion. Results are from 1 indicative mouse per group.
