Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality
J. Clin. Invest. Majed N. Aljamali, et al. 118:1825 doi:10.1172/JCI32878 [Go to this article.]

Figure 1
Transgenic construct for mFVIIa (mFVII-2RKR) and mFVII zymogen mice. The mFVIIa/mFVII cDNA is under control of the mTTR promoter separated by a synthetic intron. A polyadenylation signal (pA) from bovine growth hormone follows the 3′ untranslated region (UTR) for both cDNAs.